Anti DNA Repair Endonuclease XPF (XPF/ERCC4) mAb (Clone 19-16)

Cosmo Bio USA

Anti DNA Repair Endonuclease XPF (XPF/ERCC4) mAb (Clone 19-16)

16

Research Use Only

Nucleotide excision repair (NER) is a major repair system for removing a variety of DNA lesions including UV-induced cyclobutane pyrimidine dimers and (6-4) photoproducts as well as chemically-induced bulky base adducts. Defects in the NER system give rise to xeroderma pigmentosum (XP), an autosomal recessive disease characterized by a predisposition to skin cancer and in some cases neurological abnormalities. The early process of human NER, from damage recognition to dual incision (removal of damage-containing oligonucleotides), is accomplished by six core NER factors, XPC-RAD23B, TFIIH, XPA, RPA, XPF-ERCC1 and XPG. XPF harbors a nuclease domain and forms a stable complex with ERCC1. The ERCC1-XPF complex has a unique ability to make a nick on the DNA strand which makes the transition from duplex to single-stranded DNA in the 5 to 3 direction. In the NER process, ERCC1-XPF is responsible for 5-incision at a dual incision step.

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