Anti-DNAJC15 Antibody [SY26-04]

HUABIO

Anti-DNAJC15 Antibody [SY26-04]

7

Western Blot

WB,IHC-P

Research Use Only

Monoclonal

SY26-04

1 mg/ml

Unconjugated

DNAJC15

DnaJ heat shock protein family (Hsp40) member C15

DNAJD1, HSD18, MCJ, dnaJ homolog subfamily C member 15, DNAJ domain-containing, DnaJ (Hsp40) homolog, subfamily C, member 15, DnaJ (Hsp40) homolog, subfamily D, member 1, cell growth-inhibiting gene 22 protein, methylation-controlled J protein

Rabbit

IgG

DnaJ homolog subfamily C member 15

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. MCJ (methylation-controlled J protein), also known as HSD18, DNAJD1 or DNAJC15, is a 150 amino acid ubiquitously expressed single-pass membrane protein containing one J domain. Localizing to the golgi apparatus and only present in vertebrates, MCJ may be associated with increased chemotherapeutic resistance in ovarian cancer by inducing expression of the Mdr drug transporter and preventing intracellular drug accumulation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161