Anti-Dnmt3a Antibody [ST04-78]

HUABIO

Anti-Dnmt3a Antibody [ST04-78]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue

Research Use Only

Monoclonal

ST04-78

1 mg/ml

Unconjugated

DNMT3A

DNA methyltransferase 3 alpha

DNMT3A2, HESJAS, M.HsaIIIA, TBRS, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA MTase HsaIIIA, DNA cytosine methyltransferase 3A2, cysteine methyltransferase DNMT3A

Rabbit

IgG

DNA (cytosine-5)-methyltransferase 3A

Methylation at the 5-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161