Anti-DR4 [mAY4]

Absolute Antibody

Anti-DR4 [mAY4]

9

mAY4 was shown to bind DR4, but not other related homologs, using ELISAs and SPR (Sung et al, 2009). The mAb and scFv-reformatted version were also used in cell viability assays for assessment of tumouricidal activity. More recently, the mAY4 CDRs were humanised and expressed as an scFv-reformatted antibody fragment (Lee et al, 2010), although the humanised version had a 10-fold lower affinity for DR4.

Western Blot, ELISA, Other Application

Research Use Only

Monoclonal

mAY4

TNFRSF10A

TNF receptor superfamily member 10a

APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, cytotoxic TRAIL receptor, death receptor 4, tumor necrosis factor receptor superfamily, member 10a

Human

IgG1

Tumor necrosis factor receptor superfamily member 10A

This full-length, chimeric human antibody was made using the variable domain sequences of the original Chicken scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

41116161