Anti-DYNLL1 Antibody [SD08-04]

HUABIO

Anti-DYNLL1 Antibody [SD08-04]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

SD08-04

1 mg/ml

Unconjugated

DYNLL1

dynein light chain LC8-type 1

DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, cytoplasmic dynein light polypeptide, dynein, cytoplasmic, light polypeptide 1, protein inhibitor of neuronal nitric oxide synthase

Rabbit

IgG

Dynein light chain 1, cytoplasmic

Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. The highly conserved DYNLL proteins were originally identified as light chains for microtubule-based motor protein Dynein. In mammals there are two closely related isoforms expressed, DYNLL1 and DYNLL2 which share 93% sequence identity at the protein level. DYNLL1 (Dynein light chain 1) also designated, DLC8 or PIN (Protein inhibitor of neuronal nitric oxide synthase) has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Dimerization is required for NOS1 activity and DYNLL1 has been shown to destabilize the NOS1 dimer. Nitric oxide may be involved in several processes such as apoptosis, synaptogenesis and neuronal development; thus DYNLL1 is implicated in these processes as well. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161