Anti-Dysbindin Antibody

HUABIO

Anti-Dysbindin Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DTNBP1

dystrobrevin binding protein 1

BLOC1S8, DBND, HPS7, My031, SDY, dysbindin, BLOC-1 subunit 8, Hermansky-Pudlak syndrome 7 protein, biogenesis of lysosomal organelles complex-1, subunit 8, biogenesis of lysosome-related organelles complex 1 subunit 8, dysbindin-1

Rabbit

IgG

Dysbindin

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161