Anti-E protein [Mab 4.2]

Absolute Antibody

Anti-E protein [Mab 4.2]

9

The antibody prevented mice against challenge with a lethal dose of LIV (Gao et al., 1994; PMID: 8126456). The specificity of the scFv fragment for LIV antigen was confirmed by ELISA analysis. Immunofluorescence was performed on PS cells infected with LIV or TBEV using the scFv and the original antibody. The antibody and the scFv fragment could neutralize both LIV and TBEV (Jiang et al., 1994; PMID: 8128623). The binding affinities of the scFv fragment for LIV E and for TBEV E were measured by surface plasmon resonance (respectively 45.4 nM and 390 nM for LIV and TBEV E). The structures of the scFv fragment in complex with the envelope protein from either TBEV or LIV were determined. The antibody showed potential as a therapeutic agent (Yang et al., 2019; PMID: 30760569).

ImmunoFluorescence, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Mab 4.2

POLY

polyprotein

TBEVgp1, polyprotein, 2K protein, PreM protein, RNA-dependent RNA polymerase, anchored core protein C, core protein C, envelope protein, matrix protein M, non-structural protein NS1, non-structural protein NS2a, non-structural protein NS2b, non-structural protein NS3, non-structural protein NS4a, non-structural protein NS4b

Mouse

IgG1

Genome polyprotein

Virus

-20°C,2°C to 8°C

41116161