Anti-Ebola GP [h-13F6]

Absolute Antibody

Anti-Ebola GP [h-13F6]

7

h-13F6 binds to human FcgammaRI (CD64) and FcgammaRIII (CD16) (determined by SPR)and can confer in vitro ADCC activity and in vivo antitumor activity comparable to its fully murine parental mAb. h-13F6 also binds C1q (which is important for the first step in the classical complement cascade), and was determined by ELISA. h-13F6 also binds to mouse FcgammaRI, -II, and -III in vitro. h-13F6 has also been tested in lethal EBOV challenge mouse models where h-13F6 was shown to possess dose-dependent protectivity - equivalent protection between the original murine 13F6 and h-13F6. The antibody is unable to neutralize EBOV.

ImmunoPrecipitation, ELISA, Other Application

IP; SPR; ELISA

Research Use Only

Envelope glycoprotein

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203