Anti-ectodysplasin A [EctoD2]

Absolute Antibody

Anti-ectodysplasin A [EctoD2]

9

This antibody recognises the conserved extracellular, receptor-binding region of murine, avian and human ectodysplasin-A.

The specificity of this antibody for EDA has been confirmed in SDS-PAGE, Western blot, ELISA, native gel electrophoresis and FC experiments (Kowalczyk-Quintas et al, 2014). This antibody blocks mammalian and avian EDA1 and EDA2 from binding EDAR (Kowalczyk-Quintas et al, 2014). When administered to pregnant wild-type mice, this antibody induces foetal ectodermal dysplasia (Kowalczyk-Quintas et al, 2014). Therapeutically, this antibody may be useful in the treatment of disorders arising as a result of excessive EDA1 action.

Flow Cytometry, Western Blot, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

EctoD2

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203