Anti-eIF5A Antibody [SC60-09]

HUABIO

Anti-eIF5A Antibody [SC60-09]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,IP,FC

Research Use Only

Monoclonal

SC60-09

1 mg/ml

Unconjugated

EIF5A

eukaryotic translation initiation factor 5A

EIF-5A, EIF5A1, FABAS, eIF-4D, eIF5AI, eukaryotic translation initiation factor 5A-1, eukaryotic initiation factor 5A, rev-binding factor

Rabbit

IgG

Eukaryotic translation initiation factor 5A-1

In mammalian cells, translation is controlled at the level of polypeptide chain initiation by eukaryotic initiation factors. The human eukaryotic translation initiation factor 5A gene, also designated eIF-4D or eIF5A, maps to chromosome 17p13.1 and encodes a 154 amino acid protein that is linked to cellular polyamine homeostasis. eIF5A localizes to the nuclear and cytoplasmic compartments of mammalian cells where it can stimulate ribosomal peptidyl-transferase and may be involved in nucleocytoplasmic mRNA transport and/or protein translation. eIF5A contains a unique spermidine-derived post-translational modification at Lys-50, hypusine, which is necessary for eIF5As biochemical activity and for cellular proliferative signaling. In addition, eIF5A is a cellular cofactor for the function of the Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1). Inhibition of eIF5A interaction with Rev leads to a block of the viral replication cycle.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161