Anti-Elp3 Antibody [JE60-10]

HUABIO

Anti-Elp3 Antibody [JE60-10]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE60-10

1 mg/ml

Unconjugated

ELP3

elongator acetyltransferase complex subunit 3

KAT9, elongator complex protein 3, elongation protein 3 homolog, protein lysine acetyltransferase ELP3, tRNA uridine(34) acetyltransferase

Rabbit

IgG

Elongator complex protein 3

Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).

-20°C,2°C to 8°C

41116161