Anti-Envelop glycoprotein B [93k]

Absolute Antibody

Anti-Envelop glycoprotein B [93k]

9

This antibody targets the domain IV region of envelope glycoprotein B of the Varicella zoster virus (VZV) also known as the human herpesvirus 3 (HHV-3, HHV3) or Human alpha herpesvirus 3. This DNA virus from the herpes virus group can infect humans causin

This antibody is capable of detecting full length VZV glycoprotein B (gB) in a western blot. It was reported that this antibody could not bind to the gB R592A, I594A, or 589AAA594 mutants in western blots and binding was reduced but not abolished for the Q596A, N597A, or 596AA597 mutants (PMID: 32811830). This antibody is capable of neutralizing MRC-5 human primary fibroblast cells infected with K.McC. clinical strain of VZV virus (US5506132). It also reduced gB/gH-gL-mediated membrane fusion by 95% in the stable reporter fusion assay (SRFA) in the absence of other viral proteins (PMID: 32811830). This antibody was also used for the immunoprecipitation of gB beta23 mutants and gB/gH-gL fusion complex (PMID: 32811830).

ImmunoPrecipitation, Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

93k

Human

IgG1

Envelope glycoprotein B

Virus

-20°C,2°C to 8°C

12352203