Anti-Envelope protein DIII [2D73]

Absolute Antibody

Anti-Envelope protein DIII [2D73]

9

2D73 reacts with residues 309-319 (DKEMAETQHGT) within domain III of the DENV envelope protein, shown crystallographically (Li et al, unpublished). Although raised against DENV-3 EDIII, 2D72 cross-reacts with EDIII from all four DENV serotypes. 2D73 does

2D73 was able to strongly neutralise DENV infection in a serotype-independent manner, shown using both ELISAs and ELISPOT-based assays (Li et al, 2013). 2D73 has also been used, as a Fab fragment, to crystallise the DENV-4 EDIII protein (Li et al, unpublished).

ELISA, Other Application

Research Use Only

Monoclonal

2D73

Human

IgG1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203