Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

Absolute Antibody

Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

7

Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies o

This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Flow Cytometry, ELISA, ImmunoHistoChemistry

ELISA; FC; IHC

Research Use Only

Monoclonal

4D5-8 (trastuzumab)

ERBB2

erb-b2 receptor tyrosine kinase 2

CD340; c-erb B2/neu protein; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; VSCN2

Human

Receptor tyrosine-protein kinase erbB-2

THIS IS A RESEARCH-GRADE BIOSIMILAR. NOT FOR HUMAN THERAPY! This recombinant Fab fragement was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

-20°C,2°C to 8°C

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