Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

Absolute Antibody

Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

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This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Flow Cytometry, ELISA, ImmunoHistoChemistry

ELISA; FC; IHC

Research Use Only

Monoclonal

4D5-8 (trastuzumab)

ERBB2

erb-b2 receptor tyrosine kinase 2

CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2), receptor tyrosine-protein kinase erbB-2, c-erb B2/neu protein, herstatin, human epidermal growth factor receptor 2, metastatic lymph node gene 19 protein, neuro/glioblastoma derived oncogene homolog, neuroblastoma/glioblastoma derived oncogene homolog, proto-oncogene Neu, proto-oncogene c-ErbB-2, tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Human

IgA1

Receptor tyrosine-protein kinase erbB-2

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

-20°C,2°C to 8°C

12352203