Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

Absolute Antibody

Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]

7

Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies o

This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Flow Cytometry, ELISA, ImmunoHistoChemistry

ELISA; FC; IHC

Research Use Only

Monoclonal

4D5-8 (trastuzumab)

ERBB2

erb-b2 receptor tyrosine kinase 2

CD340; c-erb B2/neu protein; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; VSCN2

Mouse

IgG2a

Receptor tyrosine-protein kinase erbB-2

This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human HER2 (Fab) and one arm directed against human CD3e (scFv).

Human

Human

A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

-20°C,2°C to 8°C

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