Anti-ESD Antibody [J0-8]

HUABIO

Anti-ESD Antibody [J0-8]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

J0-8

2 mg/ml

Unconjugated

ESD

esterase D

FGH, S-formylglutathione hydrolase, esterase 10, esterase D/formylglutathione hydrolase, methylumbelliferyl-acetate deacetylase, testicular tissue protein Li 66

Mouse

IgG2c

S-formylglutathione hydrolase

ESD (esterase D) is also known as S-formylglutathione hydrolase and is a 282 amino acid protein that is a member of the esterase D family. ESD is highly expressed in placenta, kidney, liver and erythrocytes, and is localized to the cytoplasm, as well as to cytoplasmic vesicles. The main function of ESD is to detoxify formaldehyde while providing energy. Formaldehyde is oxidized by ADH5 which yields S-formylglutathione. ESD then catalyzes the hydrolysis of S-formylglutathione to the reduced forms of formic acid and glutathione. In addition, ESD hydrolyzes a variety of different neutral ester substrates and can act as a carboxylesterase. ESD may also act as a cysteine hydrolase which is inactivated by thiol alkylating agents. ESD gene polymorphism can lead to reduced enzymatic activity which may cause susceptibility to many conditions, including toxic liver cirrhosis, retinoblastoma, obesity and autism.

Human

Human

-20°C,2°C to 8°C

41116161