Anti-Estrogen Receptor alpha Rabbit mAb

PTM BIO

Anti-Estrogen Receptor alpha Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JRMR-11026-39B

Unconjugated

Rabbit

IgG

Estrogen receptor

Estrogen receptor alpha (ERalfa), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains. Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERalfa regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylatedrylation at multiple sites provides an important mechanism to regulate ERalfa activity. Ser104, 106, 118, and 167 are located in the amino-terminal transcription activation function domain AF-1, and Phosphorylatedrylation of these serine residues plays an important role in regulating ERalfa activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7. Ser167 may be Phosphorylatedrylated by p90RSK and Akt. According to the research literature, Phosphorylatedrylation at Ser167 may confer tamoxifen resistance in breast cancer patients.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203