Anti-Estrogen Receptor beta Antibody [JJ09-02]

HUABIO

Anti-Estrogen Receptor beta Antibody [JJ09-02]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

JJ09-02

1 mg/ml

Unconjugated

ESR2

estrogen receptor 2

ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8, estrogen receptor beta, estrogen receptor beta 2, estrogen receptor beta 4, nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta

Rabbit

IgG

Estrogen receptor beta

Estrogen receptor beta (ERbeta) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor-a nuclear receptor which is activated by the sex hormone estrogen.[5] In humans ERbeta is encoded by the ESR2 gene. ERbeta is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17-beta-estradiol, estriol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with estrogen receptor alpha that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. ERbeta may inhibit cell proliferation and opposes the actions of ERalpha in reproductive tissue. ERbeta may also have an important role in adaptive function of the lung during pregnancy. ERbeta is a potent tumor suppressor and plays a crucial role in many cancer types such as prostate cancer and ovarian cancer.

Human

Human

-20°C,2°C to 8°C

41116161