Anti-F protein [mAb 338]

Absolute Antibody

Anti-F protein [mAb 338]

9

This antibody recognizes the hMPV F protein (a.a. 238-245). Human metapneumovirus (hMPV) is a member of the Paramyxoviridae family/Pneumovirinae subfamily and shares many common features with respiratory syncytial virus (RSV), another member of the same s

ELISA was used to confirm the binding of this antibody to hMPV F protein. This antibody has been reported to have high neutralizing activity against all of the hMPV types A1, A2, B1, and B2 with an in vitro IC50 of < 2microg/ml. The antibody is effective as passive prophylaxis in protecting hamsters from HMPV challenge and also reduces incidence of MPV infection and disease in animal models (PMID: 16873237). Intraperitoneal injection of thia antibody into BALB/c mice significantly decreased lung viral titers after HMPV challenge when the antibody was administered prophylactically or therapeutically (PMID: PMID: 20619294).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

mAb 338

Human

IgG1

Fusion glycoprotein F0

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203