Anti-Factor VIII [RFF-VIII:c/8]

Absolute Antibody

Anti-Factor VIII [RFF-VIII:c/8]

9

This antibody is specific for human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 g

This antibody is a potent coagulation inhibitor (Rotblat, 1983).This antibody has been employed to produce factor VIII-deficient plasma by immunodepletion (Takase et al, 1987); purified monoclonal antibodies were bound to Sepharose columns, which were used to reduce the factor VII content of plasma through column chromatography. This antibody does not bind antigens if CRM negative haemophilic plasma, which lacks factor VIII, is used in column chromatography (Rotblat et al, 1983). This antibody has also been used in Western blotting to identify factor VIII (Rotblat et al, 1985)

Western Blot, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

RFF-VIII:c/8

F8

coagulation factor VIII

AHF; antihemophilic factor; coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; DXS1253E; F8B; F8C; factor VIII F8B; FVIII; HEMA

Mouse

IgG1

Coagulation factor VIII

Human

-20°C,2°C to 8°C

12352203