Anti-FAM38A / PIEZO1 Antibody [2-10]

HUABIO

Anti-FAM38A / PIEZO1 Antibody [2-10]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Monoclonal

2-10

2 mg/ml

Unconjugated

PIEZO1

piezo type mechanosensitive ion channel component 1 (Er blood group)

DHS, ER, FAM38A, LMPH3, LMPHM6, Mib, piezo-type mechanosensitive ion channel component 1, family with sequence similarity 38, member A, membrane protein induced by beta-amyloid treatment

Mouse

IgG2a

Piezo-type mechanosensitive ion channel component 1

Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161