Anti-Fas Mouse mAb

PTM BIO

Anti-Fas Mouse mAb

5

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry

ICC/IF, FC

Research Use Only

Monoclonal

12963

Unconjugated

Mouse

IgG

Tumor necrosis factor receptor superfamily member 6

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203