Anti-Fel d 1 [REGN1909]

Absolute Antibody

Anti-Fel d 1 [REGN1909]

9

The original human IgG4 antibody was found to block binding of wild type Fel d 1 binding to IgE with a maximum blockade of 51% in a blocking ELISA. Surface plasmon resonance was used to identify the affinity of the antibody towards recombinant and wild type Fel d 1. Crystal structure of the Fab fragment antibody was studied using X-ray crystallography. This antibody in combination with REGN1908 was found to be promising in treatment of cat allergies. A single SC dose of REGN1908-1909 in patients with cat allergy resulted in rapid and clinically meaningful reduction in total nasal symptoms by blocking the early allergic response to nasal challenge with cat allergen (PMID: 29650949).

Functional Assay, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

REGN1909

CH2

major allergen I, polypeptide chain 2

Fel d I, major allergen I polypeptide chain 2, AG4, allergen Cat-1, allergen FdI, allergen Fel d I-B

Human

IgE

Major allergen I polypeptide chain 2

This reformatted human antibody was made using the variable domain sequences of the original Human IgG4 format for improved compatibility with existing reagents assays and techniques.

Feline

-20°C,2°C to 8°C

41116161