Anti-Fel d 1 [REGN1909]

Absolute Antibody

Anti-Fel d 1 [REGN1909]

7

This antibody binds chain 2 of the Fel d 1, major cat allergen.

The original human IgG4 antibody was found to block binding of wild type Fel d 1 binding to IgE with a maximum blockade of 51% in a blocking ELISA. Surface plasmon resonance was used to identify the affinity of the antibody towards recombinant and wild type Fel d 1. Crystal structure of the Fab fragment antibody was studied using X-ray crystallography. This antibody in combination with REGN1908 was found to be promising in treatment of cat allergies. A single SC dose of REGN1908-1909 in patients with cat allergy resulted in rapid and clinically meaningful reduction in total nasal symptoms by blocking the early allergic response to nasal challenge with cat allergen (PMID: 29650949).

Functional Assay, ELISA, Neutralisation/Blocking, Other Application

ELISA; block; SPR; functional assay; crystallization

Research Use Only

Monoclonal

REGN1909

CH2

major allergen I, polypeptide chain 2

AG4; allergen Cat-1; allergen FdI; allergen Fel d I-B; Fel d I; major allergen I polypeptide chain 2

Rabbit

IgG

Major allergen I polypeptide chain 2

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format for improved compatibility with existing reagents assays and techniques.

Feline

Cat (Felis catus)

The original antibody was generated by immunizing a Regeneron’s VelocImmune human antibody producing transgenic mouse with recombinant dimeric Fel d 1.

-20°C,2°C to 8°C

12352203