Anti-FOXA2 Antibody [JM10-64]

HUABIO

Anti-FOXA2 Antibody [JM10-64]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

WB

Research Use Only

Monoclonal

JM10-64

1 mg/ml

Unconjugated

FOXA2

forkhead box A2

HNF-3-beta, HNF3B, TCF3B, hepatocyte nuclear factor 3-beta, forkhead box protein A2, hepatic nuclear factor-3-beta, transcription factor 3B

Rabbit

IgG

Hepatocyte nuclear factor 3-beta

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Human

Human

-20°C,2°C to 8°C

41116161