Anti-FUBP1 Antibody [SY11-04]

HUABIO

Anti-FUBP1 Antibody [SY11-04]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

SY11-04

1 mg/ml

Unconjugated

FUBP1

far upstream element binding protein 1

FBP, FUBP, hDH V, far upstream element-binding protein 1, DNA helicase V, FUSE binding protein 1, epididymis secretory sperm binding protein, far upstream element (FUSE) binding protein 1

Rabbit

IgG

Far upstream element-binding protein 1

Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161