Anti-GABAR [1F4]

Absolute Antibody

Anti-GABAR [1F4]

9

This antibody recognises alpha1beta2gamma2 GABA-A receptor which is found in up to 50% of the synapses in the brain. Its ligand, GABA is a major inhibitory transmitter in the nervous system, binds to this receptor and opens a channel permeable to chloride

FSEC: High affinity and specificity of the 1F4 antibody to alpha1beta2gamma2 GABA-A receptor was demonstrated using fluorescence-detection size exclusion chromatography with GFP-tagged receptor (shift in elution volume) (Zhu et al., 2018). Crystallography: Furthermore, this antibody was utilised in production and purification of the alpha1beta2gamma2 GABA-A receptor (Zhu et al., 2018). Finally, Fab fragments derived from the antibody were used to facilitate crystallisation and improve stabilisation of the alpha1beta2gamma2 GABA-A receptor (Zhu et al., 2018).

Other Application

Research Use Only

Monoclonal

1F4

GABRA1

gamma-aminobutyric acid type A receptor subunit alpha1

DEE19; ECA4; EIEE19; EJM; EJM5; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid type A receptor alpha1 subunit

Human

IgG1

Gamma-aminobutyric acid receptor subunit alpha-1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203