Anti-GARS Antibody [SC0651]

HUABIO

Anti-GARS Antibody [SC0651]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

SC0651

1 mg/ml

Unconjugated

GARS1

glycyl-tRNA synthetase 1

CMT2D, DSMAV, GARS, GlyRS, HMN5, HMN5A, HMND5, SMAD1, SMAJI, glycine--tRNA ligase, AP-4-A synthetase, Charcot-Marie-Tooth neuropathy 2D, Charcot-Marie-Tooth neuropathy, neuronal type, D, ap4A synthetase, diadenosine tetraphosphate synthetase

Rabbit

IgG

Glycine--tRNA ligase

The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Proteins belonging to this family function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. GlyRS (Glycyl-tRNA synthetase), also known as Glycine-tRNA ligase, is a 739 amino acid class II synthetase that is widely expressed, including in the brain and spinal cord. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161