Anti-GATA4 Antibody [7-4]

HUABIO

Anti-GATA4 Antibody [7-4]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

7-4

2 mg/ml

Unconjugated

Gata4

GATA binding protein 4

Gata-4, transcription factor GATA-4, GATA-binding factor 4

Mouse

IgG1

Transcription factor GATA-4

Transcriptional activator that binds to the consensus sequence 5-AGATAG-3 and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.

Human

Human

-20°C,2°C to 8°C

41116161