Anti-GC1q R Antibody [JE60-96]

HUABIO

Anti-GC1q R Antibody [JE60-96]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE60-96

1 mg/ml

Unconjugated

C1QBP

complement C1q binding protein

COXPD33, GC1QBP, HABP1, SF2AP32, SF2p32, gC1Q-R, gC1qR, p32, complement component 1 Q subcomponent-binding protein, mitochondrial, ASF/SF2-associated protein p32, C1q globular domain-binding protein, complement component 1, q subcomponent binding protein, glycoprotein gC1qBP, hyaluronan-binding protein 1, mitochondrial matrix protein p32, p33, splicing factor SF2-associated protein

Rabbit

IgG

Complement component 1 Q subcomponent-binding protein, mitochondrial

GC1q R is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria.

-20°C,2°C to 8°C

41116161