Anti-GCLM Antibody [JM39-61]

HUABIO

Anti-GCLM Antibody [JM39-61]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC,IP

Research Use Only

Monoclonal

JM39-61

1 mg/ml

Unconjugated

GCLM

glutamate-cysteine ligase modifier subunit

GLCLR, glutamate--cysteine ligase regulatory subunit, GCS light chain, GSC light chain, gamma-ECS regulatory subunit, gamma-glutamylcysteine synthetase regulatory subunit, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD), glutamate-cysteine ligase modifier subunit delta2 alternative splicing, glutamate-cysteine ligase regulatory protein

Rabbit

IgG

Glutamate--cysteine ligase regulatory subunit

Gamma-glutamylcysteine synthetase (gamma-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. gamma-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human gamma-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human gamma-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of gamma-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161