Anti-GCN2 Antibody [JA03-83]

HUABIO

Anti-GCN2 Antibody [JA03-83]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

JA03-83

1 mg/ml

Unconjugated

EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4

GCN2, PVOD2, eIF-2-alpha kinase GCN2, GCN2 eIF2alpha kinase, GCN2-like protein, general control nonderepressible 2

Rabbit

IgG

eIF-2-alpha kinase GCN2

The family of stress-responsive protein kinases include HRI (heme-regulated inhibitor or EIF2AK1), PKR (EIF2AK2 or TIK), PERK (EIF2AK3) and GCN2 (EIF2AK4). These proteins phosphorylate the eukaryotic translation initiation factor 2alpha (eIF2alpha) on Ser 51 to regulate general and gene-specific protein synthesis. Phosphorylated eIF2alpha acts as an inhibitor of its guanine nucleotide exchange factor eIF2B. GCN2, a unique eIF2alpha kinase, exists in all eukaryotes from yeast to mammals. In mammals, expression of GCN2 is highest in liver and brain tissues. GCN2 primarily initiates the phosphorylation of eIF2alpha in response to UV, but has been shown to increase phosphorylation activity in response to serum starvation. Also, substitution of Asp 83 for Ala on eIF2alpha results in impaired phosphorylation by GCN2 and PKR, suggesting a contribution of remote residues to kinase-substrate recognition.

Human

Human

-20°C,2°C to 8°C

41116161