Anti-GCN5 Mouse mAb

PTM BIO

Anti-GCN5 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

10289

Unconjugated

Mouse

IgG

Histone acetyltransferase KAT2A

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Acetylation of histones gives a specific tag for epigenetic transcription activation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203