Anti-Genome polyprotein [38-3-11A], Human IgM, kappa

Absolute Antibody

Anti-Genome polyprotein [38-3-11A], Human IgM, kappa

9

This antibody is specific for the threefold plateau epitope of the genome polyprotein of Human enterovirus 71

The original antibody was used for an in vitro neutralization assay against different EV71 genotypes. It showed neutralization for all genotypes tested. This antibody was used for a in vivo assay neutralization assay with EV71 in the hSCARB2-transgenic mice model. Here it showed increased survival in the subjects. This antibody was used for immunoprecipitation on the EV71 capsid. This antibody was used for flow cytometry on EV71 infected RD cells. The structure of this antibody was determined using both cryo-EM and x-ray crystallography (Huang et al., 2020; PMID:33067459).

Flow Cytometry, ImmunoPrecipitation, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

38-3-11A

Human

IgM

Genome polyprotein

Virus

-20°C,2°C to 8°C

12352203