Anti-Glioma surface antigen [BT32/A6]

Absolute Antibody

Anti-Glioma surface antigen [BT32/A6]

9

This antibody (BT32/A6) recognizes a surface and cytoplasmic antigen present on a variety of human tumor cell lines including gliomas, melanomas, neuroblastomas, and a few sarcomas.

The binding specificity of the IgM version of this antibody for human glioma cell lines was tested using ELISA (PMID: 1545260). Further characterization of binding of the IgM version of this antibody to SK-MG-1 and other cultured human cell lines was done using flow cytometry (US5639863; PMID: 7861227). This antibody was also used for the immunoperoxidase staining of human tumor cells (US5639863). Point mutation were introduced to increase the solubility and thermal refolding efficiency the antibody (PMID: 16971398). This antibody was also used to identify the non-human cell lines, normal human tissues, tumors of central neuroepithelial origin which express the antigen it binds (PMID: 9266445).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

BT32/A6

Human

IgG1

This reformatted human antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203