Anti-Glucocorticoid Receptor Antibody [JF0952]

HUABIO

Anti-Glucocorticoid Receptor Antibody [JF0952]

7

Flow Cytometry, ImmunoFluorescence, Western Blot

WB,FC

Research Use Only

Monoclonal

JF0952

1 mg/ml

Unconjugated

NR3C1

nuclear receptor subfamily 3 group C member 1

GCCR, GCR, GCRST, GR, GRL, glucocorticoid receptor, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Rabbit

IgG

Glucocorticoid receptor

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR alpha. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Fish, Human, Mouse, Rat

Human,Mouse,Rat,Zebrafish

-20°C,2°C to 8°C

41116161