Anti-GLUT3 + GLUT14 Rabbit mAb

PTM BIO

Anti-GLUT3 + GLUT14 Rabbit mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-3181

Unconjugated

Rabbit

IgG

Solute carrier family 2, facilitated glucose transporter member 3

A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Glucose transporter 3 (Glut3), also known as SLC2A3, has a higher affinity for glucose than the ubiquitous glucose transporter Glut1. In the normal brain, Glut3 expression is limited to neurons, whereas Glut1 is expressed in both neurons and glia. Glioblastoma-derived brain tumor initiating cells (BTICs) express increased levels of Glut3, enabling their survival in the microenvironment deficient in glucose. In addition, Glut3 expression levels correlate with poor survival in brain tumors. Glucose transporter 4 (Glut4) is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation. Translocation of Glut4 is dependent on Akt, which may act by Phosphorylatedrylating AS160, a RabGAP protein involved in membrane trafficking.The antibody can detect both GLUT3 and GLUT4.

Stable for 12 months from date of receipt/reconstitution.

Human, Rat

Human, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203