Anti-Glycoprotein E2 [HC84.26.5D (HC26AM)]

Absolute Antibody

Anti-Glycoprotein E2 [HC84.26.5D (HC26AM)]

9

This antibody recognizes a conformation dependent antigenic epitope on the E2 glycoprotein. This antibody specifically binds the antigenic domain D of the virus comprising amino acids 441, 442, 446 and 616 (PMID: 22511875).

This antibody is an affinity matured version of the original murine parent antibody HC84.26. This antibody is capable of recognizing E1E2 proteins from six different HCV genotypes and subtypes in an ELISA. This antibody is capable of neutralizing 1a and 2a HCVcc isolates of strains H77C and JFH1 (PMID: 22511875; 27641232). The original antibody was also used in the immunoprecipitation of 1a H77C recombinant E1E2 lysate (PMID: 22511875). The original antibody demonstrated synergistic effects towards the majority of the HCVccs when combined individually with AR4A (PMID: 25043937).

ImmunoPrecipitation, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

HC84.26.5D (HC26AM)

Rabbit

IgG

Genome polyprotein

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203