Anti-GPC3 CAR-T Cells
82492
CategoryCells Cell Lines
Product group Cell Culture
Overview
- SupplierBPS Bioscience
- Product NameAnti-GPC3 CAR-T Cells
- Delivery Days Customer23
- CertificationResearch Use Only
- Gene ID2719
- Target nameGPC3
- Target descriptionglypican 3
- Target synonymsDGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, glypican-3, glypican proteoglycan 3, heparan sulphate proteoglycan, intestinal protein OCI-5, secreted glypican-3
- Protein IDP51654
- Protein NameGlypican-3
- Scientific DescriptionAnti-GPC3 CAR-T Cells are produced by high-titer lentiviral transduction of human primary CD4+ and CD8+ T cells using Anti-GPC3 CAR Lentivirus (Clone GC33-CD28TM-41BB-CD3aeta) (BPS Bioscience #82494). These ready-to-use CAR-T cells express an anti-GPC3 (glypican-3) CAR (chimeric antigen receptor) consisting of the ScFv portion of anti-GPC3 (clone GC33) linked to a 2nd generation CAR, containing IgG1 short hinge and CD28 transmembrane domains, 4-1BB and CD3aeta signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine CAR expression) and co-culture cytotoxicity assays. Figure 1. Construct diagram showing components of the Anti-GPC3 CAR expressed in Anti-GPC3 CAR-T Cells.
- Storage InstructionLiquid Nitrogen
- UNSPSC41116106
- SpeciesHuman