Anti-GPIIB/IIIA [PDG7]

Absolute Antibody

Anti-GPIIB/IIIA [PDG7]

7

PDG7 does not bind to antigen denatured by heat of pH, indicating the necessity of intact GPIIb/IIIa.

Dot blots confirmed the specificity of PDG7 for GPIIB/IIIA. Inhibition assays were used to show that platelet-associated autoantibodies from AITP patients binds a closely related epitope to that of the recombinant anti-GPIIb/IIIa phage clones (Escher et al, 1998). Inhibition studies also confirmed that PDG7 inhibited binding of eluted platelet-associated autoantibodies from AITP patients to platelets (Escher et al, 1998).

inhibition assays; dot blot

PDG7

This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

Human

A phagemid library was constructed from the peripheral blood lymphocytes of a donor who was immunised with RhD+ red blood cells, and PDG7 was isolated after five rounds of affinity selection.

-20°C,2°C to 8°C

12352203