anti-GRAP2 / GADS antibody [UW40]

Arigo Biolaboratories

anti-GRAP2 / GADS antibody [UW40]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

UW40

1 mg/ml

Unconjugated

>95%

GRAP2

GRB2 related adaptor protein 2

adapter protein GRID; GADS; GRAP-2; GRB2L; GRB-2-like protein; GRB2-related adapter protein 2; GRB2-related protein with insert domain; GRBLG; GrbX; Grf40; grf-40; grf40 adapter protein; GRID; growth factor receptor-binding protein; growth factor receptor-bound protein 2-related adaptor protein 2; GRPL; hematopoietic cell-associated adapter protein GrpL; hematopoietic cell-associated adaptor protein GRPL; Mona; P38; SH3-SH2-SH3 adapter Mona; SH3-SH2-SH3 adaptor molecule

Mouse

IgG2a

GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.

Human

-20°C

12352203