anti-GRAP2 / GADS antibody [UW40]

Arigo Biolaboratories

anti-GRAP2 / GADS antibody [UW40]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

UW40

1 mg/ml

Unconjugated

>95%

GRAP2

GRB2 related adaptor protein 2

GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adapter protein 2, GRB-2-like protein, GRB2-related protein with insert domain, SH3-SH2-SH3 adapter Mona, SH3-SH2-SH3 adaptor molecule, adapter protein GRID, grf-40, grf40 adapter protein, growth factor receptor-binding protein, growth factor receptor-bound protein 2-related adaptor protein 2, hematopoietic cell-associated adapter protein GrpL, hematopoietic cell-associated adaptor protein GRPL

Mouse

IgG2a

GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.

Human

-20°C

12352203