Anti-GST3 Antibody [11D5-R]

HUABIO

Anti-GST3 Antibody [11D5-R]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

11D5-R

1 mg/ml

Unconjugated

GSTP1

glutathione S-transferase pi 1

DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI, glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III

Mouse

IgG1

Glutathione S-transferase P

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. In response to oxidative stress, upregulation of the GST family member GSTP1 occurs, consistent with this function. Furthermore, the GSTP1 gene is subject to CpG island hypermethylation, a state that correlates with human prostatic carcinogenesis. GSTP1 gene hypermethylation can be detected in urine, ejaculate and plasma from men with prostate cancer, potentially making GSTP1 a useful biomarker for prostate cancer screening.

-20°C,2°C to 8°C

41116161