Anti-HCMV gH [HCMV16]

Absolute Antibody

Anti-HCMV gH [HCMV16]

9

This antibody binds gpUL75 (gH) of the human cytomegalovirus, which is an 86-kDa glycoprotein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. It is though t

This antibody successfully precipitates glycoprotein H from both HCMV infected cell lysates and HCMV-gH-VAC-infected cell lysates. Cellular localization of HCMV-gH studied by immunofluorescence on recombinant vaccinia virus and HCMV-infected cells using HCMV-16. HCMV-16 strongly neutralizes HCMV infectivity in vitro (PMID: 2831402). The reshaped humanized antibody recognized cells infected with a variety of virus strains and neutralized clinical isolates of CMV as efficiently as laboratory strains in a conventional plaque reduction assay (PMID: 9207350).

ImmunoFluorescence, ImmunoPrecipitation, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

HCMV16

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203