Anti-HCV envelope glycoprotein E2 [AR3A ]

Absolute Antibody

Anti-HCV envelope glycoprotein E2 [AR3A ]

7

This broadly neutralizing Antibody binds the AR3 antigenic regions of the HCV envelope glycoprotein and is capable of neutralizing JFH-1, H77, H, OH8, UKN1 B12.16, J6, UKN2 A1.2, UKN2 B1.1, UKN4. 21.16, UKN5. 15.7 strains of HCV (PMID: 18064037, 22492964). The IgG1 version of AR3A inhibited the binding of E1-E2 complex to the virus co-receptor CD81 at nanomolar concentration suggesting that this antibody can block HCV interaction with CD81 and thereby inhibit infection. The binding specificity of this antibody for E2 glycoprotein was determined using ELISA. AR3A provided protective immunity in two out of five mice receiving the antibody. This (PMID:18064037). This antibody was used for the immunoprecipitation of E2 glycoprotien cell lysates (PMID: 18355410).

ImmunoPrecipitation, ELISA, Neutralisation/Blocking

ELISA; neutralize; immunotherapy; IP

Research Use Only

Genome polyprotein

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203