Anti-HCV IRES junction IIIabc [HCV2]

Absolute Antibody

Anti-HCV IRES junction IIIabc [HCV2]

9

The antibody recognizes a region located around the four-way junction structure - JIIIabc. In particular, the antibody interacts with the four unpaired nucleotides (A162, G163, U164 and A165) from the IIIa loop and an unpaired nucleotide (G233) and three

Specificity of this antibody was confirmed by ELISA tests. The antibody binds the RNA with dissociation constants of 32 +/- 7 nM specifically recognizing the so-called junction IIIabc (JIIIabc). In vitro translation assay demonstrated that the antibody binds to junction IIIabc of HCV IRES inhibiting IRES-mediated translation in a concentration-dependent manner, which indicates this antibody might be used in the development of the therapeutic agents (PMID: 31765566)

ELISA

Research Use Only

Monoclonal

HCV2

Mouse

IgG1

This chimeric mouse antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203