Anti-HDAC8 Antibody [SD082-07]
ET1612-90
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman
TargetHDAC8
Overview
- SupplierHUABIO
- Product NameAnti-HDAC8 Antibody [SD082-07]
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
- Applications SupplierWB,FC,IP
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSD082-07
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID55869
- Target nameHDAC8
- Target descriptionhistone deacetylase 8
- Target synonymsCDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS, histone deacetylase 8, histone deacetylase-like 1, protein deacetylase HDAC8, protein decrotonylase HDAC8
- HostRabbit
- IsotypeIgG
- Protein IDB1WC68
- Protein NameHistone deacetylase 8
- Scientific DescriptionHistone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation / deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Histone deacetylase 8 is involved in skull morphogenesis and metabolic control of the ERR-alpha / PGC1-alpha transcriptional complex. HDAC8 has been linked to number of disease states notably to acute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells. siRNA targeting HDAC8 showed anticancer effects. Inhibition of HDAC8 induced apoptosis has been observed in T cell lymphomas. In addition the HDAC8 enzyme has been implicated in the pathogenesis of neuroblastoma.
- ReactivityHuman
- Reactivity SupplierHuman
- Reactivity Supplier NoteMouse,Rat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161