Anti-Hemoglobin subunit alpha Antibody [SN70-09]

HUABIO

Anti-Hemoglobin subunit alpha Antibody [SN70-09]

7

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IP

Research Use Only

Monoclonal

SN70-09

1 mg/ml

Unconjugated

HBA1

hemoglobin subunit alpha 1

ECYT7, HBA-T3, HBH, METHBA, hemoglobin subunit alpha, alpha globin chain, alpha one globin, alpha-2 globin chain, delta globin, hemoglobin alpha 1 globin chain, hemoglobin, alpha 1

Rabbit

IgG

Hemoglobin subunit alpha

Hemoglobin (Hgb) is coupled to four iron-binding, methene-linked tetrapyrrole rings (heme). The alpha (16p13.3; 5-aeta-pseudoz-pseudo alpha2-pseudo alpha1-alpha2-alpha1-?1-3) and beta (11p15.5) globin loci determine the basic hemoglobin structure. The globin portion of hemoglobin consists of two alpha chains and two beta chains arranged in pairs forming a tetramer. Each of the four globin chains covalently associates with a heme group. The bonds between alpha and beta chains are weaker than between similar globin chains, thereby forming a cleavage plane that is important for oxygen binding and release. High affinity for oxygen occurs upon relaxation of the alpha1-beta2 cleavage plane. When the two alpha1-beta2 interfaces are closely bound, hemoglobin has a low affinity for oxygen. Hb A, which contains two alpha chains plus two beta chains, comprises 97% of total circulating hemoglobin. The remaining 3% of total circulating hemoglobin is comprised of Hb A-2, which consists of two alpha chains plus two delta chains, and fetal hemoglobin (Hb F), which consists of two alpha chains together with two gamma chains.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161