Anti-Hepatitis A virus capsid [R10]

Absolute Antibody

Anti-Hepatitis A virus capsid [R10]

9

This antibody potently and specifically binds to the surface of Hepatitis A viral particles, along the interfaces of the viral pentameric assemblies.

This neutralising antibody blocks Hepatitis A virus attachment to host cell receptors and interferes with viral uncoating (Wang et al, 2017). This antibody recognises conformational epitopes by ELISA, but not linear epitopes in immunoblot analysis (Wang et al, 2017). A Fab derived from this antibody has been used to determine the structure of Hepatitis A viral particles, through both cryo-EM microscopy and X-ray crystallography (Wang et al, 2017).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

R10

Mouse

IgG2a

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203