Anti-hepsin [Mab55]

Absolute Antibody

Anti-hepsin [Mab55]

9

The antibody is specific for hepsin and cross-reacts with cynomolgus hepsin. Human hepsin is a Type II serine transmembrane protease and belongs to the trypsin family of serine proteases. Hepsin was identified by homology screening of a human liver cDNA l

The crystal structure of the Fab fragment of the antibody in complex with hHepsin was determined. The binding affinity of the Fab fragments to hHepsin was measured by surface plasmon resonance (Kd= 39.8 nM). The original antibody could inhibit hepsin. The original antibody could detect hepsin expressed in HEK293 cells by flow cytometry and confocal microscopy analysis (WO2011161189A1).

Flow Cytometry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Mab55

HPN

hepsin

serine protease hepsin; testicular tissue protein Li 85; TMPRSS1; transmembrane protease serine 1

Rabbit

IgG

Serine protease hepsin

Human, Monkey

-20°C,2°C to 8°C

12352203